Importance of the aromatic ring in adrenergic amines. 5. Nonaromatic analogues of phenylethanolamine as inhibitors of phenylethanolamine N-methyltransferase: role of hydrophobic and steric interactions

J Med Chem. 1981 Jan;24(1):7-12. doi: 10.1021/jm00133a003.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Hydroxyphenethylamine / chemical synthesis*
  • 2-Hydroxyphenethylamine / pharmacology
  • Adrenal Medulla / enzymology
  • Animals
  • Cattle
  • Chemical Phenomena
  • Chemistry
  • Chemistry, Physical
  • In Vitro Techniques
  • Molecular Conformation
  • Phenethylamines / chemical synthesis*
  • Phenylethanolamine N-Methyltransferase / antagonists & inhibitors*
  • Structure-Activity Relationship

Substances

  • Phenethylamines
  • 2-Hydroxyphenethylamine
  • Phenylethanolamine N-Methyltransferase